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Microbial community dynamics at high organic loading rates revealed by pyrosequencing during sugar refinerywastewater treatment in a UASB reactor

Liguo Zhang, Qiaoying Ban, Jianzheng Li

《环境科学与工程前沿（英文）》 2018年 第12卷 第4期 doi: 10.1007/s11783-018-1045-8

摘要：

High strength sugar refinery wastewater was treated in a mesophilic UASB.

Pyrosequencing reveals microbial community succession with OLR increase.

Diversity of microbial communities in OLR12 is much higher than those in OLR36 and OLR54.0 kgCOD/(kg VSS·d).

Fermentative bacteria could deal with increasing OLR through the increase of microbial diversity and quantity.

Hydrogen-producing acotogens and methanogens mainly coped with high OLR shocks by increasing the quantity of community

关键词： Upflow anaerobic sludge blanket     Sugar refinery wastewater     Organic loading rate     Pyrosequencing     Microbial community structure    

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Fermentative hydrogen production from beet sugar factory wastewater treatment in a continuous stirred

Gefu ZHU, Chaoxiang LIU, Jianzheng LI, Nanqi REN, Lin LIU, Xu HUANG

《环境科学与工程前沿（英文）》 2013年 第7卷 第1期   页码 143-150 doi: 10.1007/s11783-012-0456-1

摘要： A low pH, ethanol-type fermentation process was evaluated for wastewater treatment and bio-hydrogen production from acidic beet sugar factory wastewater in a continuous stirred tank reactor (CSTR) with an effective volume of 9.6 L by anaerobic mixed cultures in this present study. After inoculating with aerobic activated sludge and operating at organic loading rate (OLR) of 12 kgCOD?m ·d , HRT of 8h, and temperature of 35°C for 28 days, the CSTR achieved stable ethanol-type fermentation. When OLR was further increased to 18 kgCOD?m ·d on the 53rd day, ethanol-type fermentation dominant microflora was enhanced. The liquid fermentation products, including volatile fatty acids (VFAs) and ethanol, stabilized at 1493 mg·L in the bioreactor. Effluent pH, oxidation-reduction potential (ORP), and alkalinity ranged at 4.1–4.5, -250–(-290) mV, and 230–260 mgCaCO ?L . The specific hydrogen production rate of anaerobic activated sludge was 0.1 L?gMLVSS ·d and the COD removal efficiency was 45%. The experimental results showed that the CSTR system had good operation stability and microbial activity, which led to high substrate conversion rate and hydrogen production ability.

关键词： fermentative hydrogen production     continuous stirred tank reactor (CSTR)     specific hydrogen production rate     beet sugar factory wastewater     ethanol-type fermentation    

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Enterprise-wide optimization of integrated planning and scheduling for refinery-petrochemical complex

《化学科学与工程前沿（英文）》 2023年 第17卷 第10期   页码 1516-1532 doi: 10.1007/s11705-022-2283-7

摘要： This paper focuses on the integrated problem of long-term planning and short-term scheduling in a large-scale refinery-petrochemical complex, and considers the overall manufacturing process from the upstream refinery to the downstream petrochemical site. Different time scales are incorporated from the planning and scheduling subproblems. At the end of each discrete time period, additional constraints are imposed to ensure material balance between different time scales. Discrete time representation is applied to the planning subproblem, while continuous time is applied to the scheduling of ethylene cracking and polymerization processes in the petrochemical site. An enterprise-wide mathematical model is formulated through mixed integer nonlinear programming. To solve the problem efficiently, a heuristic algorithm combined with a convolutional neural network (CNN), is proposed. Binary variables are used as the CNN input, leading to the integration of a data-driven approach and classical optimization by which a heuristic algorithm is established. The results do not only illustrate the detailed operations in a refinery and petrochemical complex under planning and scheduling, but also confirm the high efficiency of the proposed algorithm for solving large-scale problems.

关键词： planning     scheduling     refinery-petrochemical     convolutional neural network     heuristic algorithm    

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Impact of crude distillation unit model accuracy on refinery production planning

Gang FU, Pedro A. Castillo CASTILLO, Vladimir MAHALEC

《工程管理前沿（英文）》 2018年 第5卷 第2期   页码 195-201 doi: 10.15302/J-FEM-2017052

摘要： In this work, we examine the impact of crude distillation unit (CDU) model errors on the results of refinery-wide optimization for production planning or feedstock selection. We compare the swing cut+ bias CDU model with a recently developed hybrid CDU model (Fu et al., 2016). The hybrid CDU model computes material and energy balances, as well as product true boiling point (TBP) curves and bulk properties (e.g., sulfur % and cetane index, and other properties). Product TBP curves are predicted with an average error of 0.5% against rigorous simulation curves. Case studies of optimal operation computed using a planning model that is based on the swing cut+ bias CDU model and using a planning model that incorporates the hybrid CDU model are presented. Our results show that significant economic benefits can be obtained using accurate CDU models in refinery production planning.

关键词： impact of model accuracy on production planning     swing cut+ bias CDU model     hybrid CDU model     refinery feedstock selection optimization     optimization of refinery operation    

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Lessons learned from developing and implementing refinery production scheduling technologies

Marcel JOLY, Mario Y. MIYAKE

《工程管理前沿（英文）》 2017年 第4卷 第3期   页码 325-337 doi: 10.15302/J-FEM-2017033

摘要： An increasing number of novel and highly specialized computer-aided decision-making technologies for short-term production scheduling in oil refineries has emerged and evolved over the past two decades, thereby encouraging refiners to permanently rethink the way the refining business is operated and managed. In this report, we discuss the key lessons learned from one of the pioneering, yet daring, enterprise-wide programs entirely implemented in an energy company devoted to developing and implementing an advanced refinery production scheduling (RPS) technology, i.e., the RPS system of Petrobras. Apart from mathematical and information technology issues, the long-term sustainability of a successful RPS project is, we argue, the outcome of a virtuous cycle grounded on permanent actions devoted to improving technical education inside the organization, reinspecting organizational cultures and operational paradigms, and developing working processes.

关键词： automation     decision making     oil refinery     optimization     production scheduling    

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Greenhouse gas emissions mitigation and economic viability of sugar crops in China

《农业科学与工程前沿（英文）》 doi: 10.15302/J-FASE-2023529

摘要：

● Sugarcane and sugar beet yield and carbon footprint rose with time but profit declined

关键词： Economic profits     GHG emissions     labor input     nitrogen input     sugar    

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Heat Integration retrofit analysis—an oil refinery case study by Retrofit Tracing Grid Diagram

Andreja NEMET, Jiří Jaromír KLEMEŠ, Petar Sabev VARBANOV, Valter MANTELLI

《化学科学与工程前沿（英文）》 2015年 第9卷 第2期   页码 163-182 doi: 10.1007/s11705-015-1520-8

摘要： Heat Integration has been established over the last decades as a proven chemical engineering methodology. Two design implementations are often used in the industry: grassroots and retrofit. Although various methods have been developed for retrofit, it still needs more development to ensure simultaneously thermodynamic feasibility and economic viability. In this paper, a novel graphical approach has been developed to facilitate the understanding of the current situation and scope of improvement. The Retrofit Tracing Grid Diagram presents all streams and heat exchangers in temperature scale and the heat exchangers are clearly separated from each other, enabling clear visualisation of the current state. The tool incorporates the previously developed Cross-Pinch Analysis as well as path approach for retrofit. Additionally, the non-vertical heat transfer can be evaluated. The application of the developed tool has been validated on an oil refinery case study. The applicability of the tool is evident as it can reveal additional options for modification that none of the previous methods considered.

关键词： Heat Integration     retrofit     Pinch Analysis     thermodynamic approach     oil refinery    

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Multiple input self-organizing-map ResNet model for optimization of petroleum refinery conversion units

《化学科学与工程前沿（英文）》 2023年 第17卷 第6期   页码 759-771 doi: 10.1007/s11705-022-2269-5

摘要： This work introduces a deep-learning network, i.e., multi-input self-organizing-map ResNet (MISR), for modeling refining units comprised of two reactors and a separation train. The model is comprised of self-organizing-map and the neural network parts. The self-organizing-map part maps the input data into multiple two-dimensional planes and sends them to the neural network part. In the neural network part, residual blocks enhance the convergence and accuracy, ensuring that the structure will not be overfitted easily. Development of the MISR model of hydrocracking unit also benefits from the utilization of prior knowledge of the importance of the input variables for predicting properties of the products. The results show that the proposed MISR structure predicts more accurately the product yields and properties than the previously introduced self-organizing-map convolutional neural network model, thus leading to more accurate optimization of the hydrocracker operation. Moreover, the MISR model has smoother error convergence than the previous model. Optimal operating conditions have been determined via multi-round-particle-swarm and differential evolution algorithms. Numerical experiments show that the MISR model is suitable for modeling nonlinear conversion units which are often encountered in refining and petrochemical plants.

关键词： hydrocracking     convolutional neural networks     self-organizing map     deep learning     data-driven optimization    

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neural network-based production process modeling and variable importance analysis approach in corn to sugar

《化学科学与工程前沿（英文）》 2023年 第17卷 第3期   页码 358-371 doi: 10.1007/s11705-022-2190-y

摘要： Corn to sugar process has long faced the risks of high energy consumption and thin profits. However, it’s hard to upgrade or optimize the process based on mechanism unit operation models due to the high complexity of the related processes. Big data technology provides a promising solution as its ability to turn huge amounts of data into insights for operational decisions. In this paper, a neural network-based production process modeling and variable importance analysis approach is proposed for corn to sugar processes, which contains data preprocessing, dimensionality reduction, multilayer perceptron/convolutional neural network/recurrent neural network based modeling and extended weights connection method. In the established model, dextrose equivalent value is selected as the output, and 654 sites from the DCS system are selected as the inputs. LASSO analysis is first applied to reduce the data dimension to 155, then the inputs are dimensionalized to 50 by means of genetic algorithm optimization. Ultimately, variable importance analysis is carried out by the extended weight connection method, and 20 of the most important sites are selected for each neural network. The results indicate that the multilayer perceptron and recurrent neural network models have a relative error of less than 0.1%, which have a better prediction result than other models, and the 20 most important sites selected have better explicable performance. The major contributions derived from this work are of significant aid in process simulation model with high accuracy and process optimization based on the selected most important sites to maintain high quality and stable production for corn to sugar processes.

关键词： big data     corn to sugar factory     neural network     variable importance analysis    

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

《化学科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 482-489 doi: 10.1007/s11705-013-1342-5

摘要： In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps: lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0, 2% enzyme/substrate (E/S) ratio, 15 h, and a solid to liquid ratio of 1 ∶ 10. The pectic extract showed a degree of polymerization (DP) profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5–25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen (4-OHT), a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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Refinery production scheduling toward Industry 4.0

Marcel JOLY, Darci ODLOAK, Mario Y. MIYAKE, Brenno C. MENEZES, Jeffrey D. KELLY

《工程管理前沿（英文）》 2018年 第5卷 第2期   页码 202-213 doi: 10.15302/J-FEM-2017024

摘要： Understanding the holistic relationship between refinery production scheduling (RPS) and the cyber-physical production environment with smart scheduling is a new question posed in the study of process systems engineering. Here, we discuss state-of-the-art RSPs in the crude-oil refining field and present examples that illustrate how smart scheduling can impact operations in the high-performing chemical process industry. We conclude that, more than any traditional off-the-shelf RPS solution available today, flexible and integrative specialized modeling platforms will be increasingly necessary to perform decentralized and collaborative optimizations, since they are the technological alternatives closer to the advanced manufacturing philosophy.

关键词： cyber-physical systems     optimization     petrochemical industry     scheduling     smart manufacturing    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

《医学前沿（英文）》 2022年 第16卷 第3期   页码 322-338 doi: 10.1007/s11684-021-0901-2

摘要： Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

关键词： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive cell therapy    

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hydrothermal carbon supporting metal oxide nanoparticles as efficient catalyst for mono-dehydration of sugar

Cheng PAN, Chao FAN, Wanqin WANG, Teng LONG, Benhua HUANG, Donghua ZHANG, Peigen SU, Aqun ZHENG, Yang SUN

《能源前沿（英文）》 2022年 第16卷 第5期   页码 822-839 doi: 10.1007/s11708-020-0677-0

摘要： Most known catalytic dehydration of sugar alcohols such as D-sorbitol and D-mannitol can only produce di-dehydrated forms as major product, but mono-dehydrated products are also useful chemicals. Moreover, both di- and mono-dehydration demand a high temperature (150°C or higher), which deserves further attentions. To improve the mono-dehydration efficiency, a series of metal-containing hydrothermal carbonaceous materials (HTC) are prepared as catalyst in this work. Characterization reveals that the composition of preparative solution has a key influence on the morphology of HTC. In transformation of D-sorbitol, all HTC catalysts show low conversions in water regardless of temperature, but much better outputs are obtained in ethanol, especially at a higher temperature. When D-mannitol is selected as substrate, moderate to high conversions are obtained in both water and ethanol. On the other hand, high mono-dehydration selectivity is obtained for both sugar alcohols by using all catalysts. The origin of mono-dehydration selectivity and role of carbon component in catalysis are discussed in association with calculations. This study provides an efficient, mild, eco-friendly, and cost-effective system for mono-dehydration of sugar alcohols, which means a lot to development in new detergents or other fine chemicals.

关键词： hydrothermal carbon     morphology     catalyst     mono-dehydration     sugar alcohol    

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Electrochemical sensor investigation of carbon-supported PdCoAg multimetal catalysts using sugar-containing

Firat Salman, Hilal C. Kazici, Hilal Kivrak

《化学科学与工程前沿（英文）》 2020年 第14卷 第4期   页码 629-638 doi: 10.1007/s11705-019-1840-1

摘要： Novel PdCoAg/C nanostructures were successfully synthesized by the polyol method in order to develop electrocatalysts, related to the glucose sensor performance of the high glycemic index in beverages. The characterization of this novel PdCoAg/C electrocatalyst was performed by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and high-resolution transmission electron microscopy equipped with energy dispersive X-ray. The characterization results revealed that electronic state of the PdCoAg/C electrocatalyst was modified by the addition of the third metal. The electrochemical performances of the sensor were investigated by cyclic voltammetry and differential pulse voltammetry. The prepared enzyme-free sensor exhibited excellent catalytic activity against glucose with a wide detection range (0.005 to 0.35 mmol∙L ), low limit of detection (0.003 mmol∙L ), high sensitivity (4156.34 µA∙mmol ∙L∙cm ), and long-term stability (10 days) because of the synergistic effect between the ternary metals. The glucose contents of several energy drinks, fruit juices, and carbonated beverages were analyzed using the novel PdCoAg/NGCE/C sensor system. These results indicate the feasibility for applications in the foods industry.

关键词： non-enzymatic     glucose detection     ternary metals     glycemic index     beverages    

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矢志不渝——为了心脏健康，与糖和脂肪“作斗争”

杨宝峰, 王睿

《工程（英文）》 2023年 第20卷 第1期   页码 1-2 doi: 10.1016/j.eng.2022.10.003

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标题 作者 时间 类型 操作

Microbial community dynamics at high organic loading rates revealed by pyrosequencing during sugar refinerywastewater treatment in a UASB reactor

Liguo Zhang, Qiaoying Ban, Jianzheng Li

期刊论文

Fermentative hydrogen production from beet sugar factory wastewater treatment in a continuous stirred

Gefu ZHU, Chaoxiang LIU, Jianzheng LI, Nanqi REN, Lin LIU, Xu HUANG

期刊论文

Enterprise-wide optimization of integrated planning and scheduling for refinery-petrochemical complex

期刊论文

Impact of crude distillation unit model accuracy on refinery production planning

Gang FU, Pedro A. Castillo CASTILLO, Vladimir MAHALEC

期刊论文

Lessons learned from developing and implementing refinery production scheduling technologies

Marcel JOLY, Mario Y. MIYAKE

期刊论文

Greenhouse gas emissions mitigation and economic viability of sugar crops in China

期刊论文

Heat Integration retrofit analysis—an oil refinery case study by Retrofit Tracing Grid Diagram

Andreja NEMET, Jiří Jaromír KLEMEŠ, Petar Sabev VARBANOV, Valter MANTELLI

期刊论文

Multiple input self-organizing-map ResNet model for optimization of petroleum refinery conversion units

期刊论文

neural network-based production process modeling and variable importance analysis approach in corn to sugar

期刊论文

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

期刊论文

Refinery production scheduling toward Industry 4.0

Marcel JOLY, Darci ODLOAK, Mario Y. MIYAKE, Brenno C. MENEZES, Jeffrey D. KELLY

期刊论文

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

期刊论文

hydrothermal carbon supporting metal oxide nanoparticles as efficient catalyst for mono-dehydration of sugar

Cheng PAN, Chao FAN, Wanqin WANG, Teng LONG, Benhua HUANG, Donghua ZHANG, Peigen SU, Aqun ZHENG, Yang SUN

期刊论文

Electrochemical sensor investigation of carbon-supported PdCoAg multimetal catalysts using sugar-containing

Firat Salman, Hilal C. Kazici, Hilal Kivrak

期刊论文

矢志不渝——为了心脏健康，与糖和脂肪“作斗争”

杨宝峰, 王睿

期刊论文